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Assessing the lung cancer risk reduction potential of cMRTPs is hampered by (i) the absence of clinical risk markers that are predictive of future lung cancer development, (ii) the latency of lung cancer manifestation (decades of smoking), and (iii) the slow reduction in excess risk upon cessation and a fortiori upon switching to a cMRTP

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This design maintains an open airway, preventing the end from becoming crushed during use

High quality, German made Denicotea cigarette holder reduce tar and nicotine using silica gel filters